Introduction

PIRFENOID 400 contains Pirfenidone (400mg), a well-known antifibrotic agent primarily used to treat Idiopathic Pulmonary Fibrosis (IPF). This chronic lung disease leads to progressive scarring of lung tissues, making breathing increasingly difficult. Pirfenidone (400mg) helps slow the progression of the disease by reducing inflammation and fibrosis in lung tissues.

Key Ingredients

• Pirfenidone (400mg) – The active ingredient responsible for antifibrotic and anti-inflammatory properties.

• Excipients – Additional inactive ingredients that enhance stability and absorption.

How Pirfenidone (400mg) Works

Pirfenidone (400mg) works by targeting multiple pathways involved in lung fibrosis:

1. Anti-Inflammatory Action – Reduces the production of pro-inflammatory cytokines, such as TNF-alpha and interleukins, which contribute to lung damage.

2. Antifibrotic Effects – Inhibits fibroblast proliferation and collagen synthesis, preventing excessive scarring of lung tissues.

3. Oxidative Stress Reduction – Helps neutralize oxidative damage, which plays a crucial role in the progression of Idiopathic Pulmonary Fibrosis (IPF).

Uses of PIRFENOID 400

• Idiopathic Pulmonary Fibrosis (IPF) – Slows disease progression and improves lung function.

• Pulmonary Fibrosis of Other Causes – May be prescribed in some cases where lung scarring results from environmental factors or autoimmune diseases.

• Off-Label Uses – Investigated for potential benefits in liver fibrosis, kidney fibrosis, and other fibrotic conditions.

Recommended Dosage

• Starting Dose: Generally, Pirfenidone (400mg) is initiated at a low dose and gradually increased to minimize side effects.

• Maintenance Dose: Standard dosage includes 3 tablets per day (one with each meal), as per physician recommendations.

• Adjustments: Patients with liver or kidney impairments may require dose modifications.

Benefits of Pirfenidone (400mg)

• Slows Lung Function Decline – Helps maintain better respiratory capacity over time.

• Reduces Inflammation – Minimizes lung tissue inflammation to prevent excessive scarring.

• Improves Quality of Life – Supports better oxygenation and overall lung health.

• Potential Antioxidant Effects – Reduces oxidative stress-related damage.

Side Effects of Pirfenidone (400mg)

Although Pirfenidone (400mg) is generally well-tolerated, some patients may experience side effects:

Common Side Effects:

• Nausea and Vomiting

• Loss of Appetite

• Skin Rash and Sensitivity to Sunlight

• Fatigue and Dizziness

Rare but Serious Side Effects:

• Liver Dysfunction – Requires regular liver function monitoring.

• Gastrointestinal Issues – Severe nausea, diarrhea, or stomach pain.

• Photosensitivity Reactions – Patients should use sunscreen and avoid excessive sun exposure.

• Allergic Reactions – Severe itching, swelling, or breathing difficulties.

Precautions and Warnings

• Liver Monitoring: Regular liver function tests are advised for patients taking Pirfenidone (400mg).

• Kidney Impairment: Dose adjustments may be required in patients with renal conditions.

• Avoid Alcohol: Alcohol consumption should be limited to prevent liver toxicity.

• Sun Protection: Due to increased photosensitivity, sunscreen and protective clothing are recommended.

• Pregnancy and Breastfeeding: Not recommended unless prescribed by a physician.

Drug Interactions

• CYP1A2 Inhibitors (e.g., Ciprofloxacin, Fluvoxamine) – May increase Pirfenidone (400mg) levels in the blood, leading to toxicity.

• Smoking – Reduces drug efficacy; smokers may require dose adjustments.

• Antacids and Proton Pump Inhibitors – May interfere with absorption and effectiveness.

• Immunosuppressants (e.g., Methotrexate, Azathioprine) – Should be used cautiously due to potential additive effects on liver toxicity.

Storage Instructions

• Store PIRFENOID 400 at room temperature (15-30°C) in a dry place.

• Keep away from direct sunlight and moisture.

• Ensure it is out of reach of children.

Frequently Asked Questions (FAQs)

1. How long does Pirfenidone (400mg) take to show results?

Most patients may notice improvements within 3 to 6 months, but consistent usage as prescribed is necessary for optimal benefits.

2. Can I stop taking Pirfenidone (400mg) if I feel better?

No, stopping the medication abruptly can worsen lung function decline. Always consult a doctor before discontinuing.

3. Is Pirfenidone (400mg) a cure for Idiopathic Pulmonary Fibrosis?

No, it is not a cure but significantly slows disease progression and improves lung function.

4. Can PIRFENOID 400 be taken on an empty stomach?

It is recommended to take Pirfenidone (400mg) with food to reduce the risk of stomach irritation.

5. What should I do if I miss a dose?

Take the missed dose as soon as you remember, but do not double the next dose to compensate.

Price and Availability in India

The price of PIRFENOID 400 varies depending on the manufacturer and pharmacy location. Generally, a pack of Pirfenidone (400mg) tablets costs between ₹3,500 to ₹7,000 per month. Patients may check for discounts, government schemes, or insurance coverage for affordability.

Conclusion

PIRFENOID 400 containing Pirfenidone (400mg) is a crucial medication for managing Idiopathic Pulmonary Fibrosis (IPF). By slowing lung function decline, reducing inflammation, and improving quality of life, it plays a vital role in treating fibrotic lung diseases. Patients should adhere to prescribed dosages, take precautions, and undergo regular medical monitoring to ensure safety and effectiveness. Always consult a healthcare professional before starting or modifying any treatment involving Pirfenidone (400mg).

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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