Introduction

OXIFYLINE PR 400 is a pharmaceutical product that contains Pentoxifylline (400mg) as its active ingredient. Pentoxifylline is a phosphodiesterase inhibitor, primarily used to improve blood flow and treat conditions related to poor circulation. It is most commonly prescribed for peripheral arterial disease (PAD), chronic venous insufficiency (CVI), and diabetic neuropathy. This article aims to provide a comprehensive understanding of OXIFYLINE PR 400, including its uses, dosage, side effects, mechanism of action, and more.

What is Pentoxifylline (400mg)?

Pentoxifylline, the active ingredient in OXIFYLINE PR 400, is a medication that works by improving blood flow and reducing blood viscosity. It is particularly beneficial for patients suffering from circulatory problems where blood flow is impaired. By enhancing the flexibility of red blood cells and making the blood less thick, Pentoxifylline can improve circulation and reduce symptoms associated with poor circulation, such as pain, cramping, and numbness in the legs and arms.

Pentoxifylline has a wide range of therapeutic applications due to its ability to improve tissue oxygenation and prevent damage to blood vessels. OXIFYLINE PR 400 is typically used in chronic conditions, where circulation is continuously compromised.

Key Benefits of OXIFYLINE PR 400

1. Improved Circulation: The primary benefit of OXIFYLINE PR 400 is its ability to enhance blood flow, especially in patients with peripheral vascular diseases. This helps alleviate discomfort caused by poor circulation, such as leg cramps, numbness, and tingling.

2. Treatment of Peripheral Arterial Disease (PAD): Pentoxifylline is widely used to treat PAD, a condition where narrowing of the arteries leads to reduced blood flow to the limbs. By improving blood flow, OXIFYLINE PR 400 helps in managing the symptoms of PAD, including pain while walking, cold extremities, and muscle cramping.

3. Support for Diabetic Neuropathy: People with diabetic neuropathy often experience damage to the nerves due to poor blood circulation. OXIFYLINE PR 400 can help improve the circulation to the nerves, providing relief from symptoms such as burning, tingling, and numbness in the hands and feet.

4. Chronic Venous Insufficiency (CVI): In patients with CVI, the veins in the legs fail to efficiently return blood to the heart. OXIFYLINE PR 400 improves blood flow and reduces symptoms such as swelling, pain, and heaviness in the legs.

5. Antioxidant Properties: Pentoxifylline also has antioxidant effects, which help in protecting the blood vessels from oxidative stress and inflammation, further promoting healthy circulation.

How Does OXIFYLINE PR 400 Work?

The active ingredient, Pentoxifylline (400mg), exerts its effects by inhibiting phosphodiesterase enzymes, which results in an increase in cyclic adenosine monophosphate (cAMP) levels in the smooth muscle cells of the blood vessels. This leads to vasodilation (widening of blood vessels), thereby improving blood flow and reducing blood viscosity.

Additionally, Pentoxifylline enhances erythrocyte flexibility (red blood cells), allowing them to pass through smaller capillaries and improve oxygen delivery to tissues. This is particularly important for individuals suffering from poor circulation, where red blood cells are often unable to pass through narrow or clogged blood vessels efficiently.

Indications for OXIFYLINE PR 400

OXIFYLINE PR 400 is indicated for the treatment of:

1. Peripheral Arterial Disease (PAD): A condition where the arteries become narrowed or blocked, leading to reduced blood flow, especially in the legs.

2. Chronic Venous Insufficiency (CVI): A condition that occurs when the veins in the legs are unable to return blood to the heart effectively, leading to symptoms such as swelling and pain.

3. Diabetic Neuropathy: Nerve damage caused by diabetes that often results from poor circulation and reduced blood flow to the extremities.

4. Post-Surgical Recovery: In certain cases, OXIFYLINE PR 400 may be used to support recovery after surgery, particularly in cases where circulation is impaired due to the surgical procedure.

5. Raynaud’s Disease: This is a condition that affects blood flow to the extremities, particularly the fingers and toes, causing them to turn white or blue in response to cold or stress. OXIFYLINE PR 400 may help improve blood flow and reduce the frequency of attacks.

Dosage and Administration

The dosage of OXIFYLINE PR 400 depends on the condition being treated and the patient's overall health. It is essential to follow the healthcare provider's prescription guidelines when taking this medication. A typical dose for adults is:

• Pentoxifylline (400mg): One tablet of OXIFYLINE PR 400 should be taken two to three times a day with food to reduce gastrointestinal side effects.

It is important to not exceed the prescribed dosage to avoid potential side effects.

Side Effects of OXIFYLINE PR 400

Like any medication, OXIFYLINE PR 400 may cause side effects. Common side effects of Pentoxifylline (400mg) include:

1. Gastrointestinal Issues: Nausea, vomiting, indigestion, or diarrhea are common side effects associated with Pentoxifylline.

2. Headache: Some patients may experience headaches, dizziness, or lightheadedness.

3. Skin Reactions: Rash, itching, or redness of the skin may occur in some individuals.

4. Cardiovascular Effects: Rarely, OXIFYLINE PR 400 may cause tachycardia (rapid heart rate), hypotension (low blood pressure), or arrhythmias.

5. Bleeding Disorders: Since Pentoxifylline can reduce blood viscosity, there is a potential for increased bleeding risk, especially in patients who are already taking anticoagulant medications.

If any severe side effects or allergic reactions (e.g., difficulty breathing, swelling of the face, lips, or throat) occur, medical attention should be sought immediately.

Precautions and Warnings

1. Pregnancy and Breastfeeding: The safety of OXIFYLINE PR 400 during pregnancy and breastfeeding has not been well-established. It is important to consult a healthcare provider before using this medication during these periods.

2. Liver and Kidney Impairment: Patients with liver or kidney conditions should use OXIFYLINE PR 400 with caution. Dose adjustments may be necessary for individuals with severe liver or kidney disease.

3. Bleeding Risk: Individuals who have a bleeding disorder or are taking anticoagulant therapy should use OXIFYLINE PR 400 cautiously. It may increase the risk of bleeding, especially during surgeries or invasive procedures.

4. Drug Interactions: OXIFYLINE PR 400 may interact with other medications, particularly anticoagulants, antiplatelet drugs, and blood pressure medications. Inform your doctor about all the medications you are taking.

OXIFYLINE PR 400 Price and Availability

The price of OXIFYLINE PR 400 varies depending on the country, pharmacy, and insurance coverage. In general, the cost of Pentoxifylline (400mg) tablets ranges from ₹50 to ₹150 for a pack containing 10 to 30 tablets in India. It is available both as a branded product and in generic formulations, which may affect the cost.

OXIFYLINE PR 400 is widely available in pharmacies and can also be obtained through online pharmacies.

Conclusion

OXIFYLINE PR 400 is an effective and well-tolerated medication for treating various circulatory issues related to peripheral arterial disease, chronic venous insufficiency, and diabetic neuropathy. The active ingredient, Pentoxifylline (400mg), works by improving blood flow and reducing blood viscosity, which helps alleviate symptoms of poor circulation and supports tissue oxygenation.

While OXIFYLINE PR 400 is generally safe for use, it is important to follow dosage instructions and consult with a healthcare provider for individualized treatment. As with any medication, patients should be aware of potential side effects and take necessary precautions, especially if they have underlying health conditions.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW