Introduction

OXIFYLINE PR 400 is a prescription medication that contains Pentoxifylline (400mg) as its active ingredient. It belongs to a class of drugs known as xanthine derivatives and is primarily used to improve blood circulation in conditions such as chronic occlusive arterial diseases and peripheral vascular diseases. By enhancing red blood cell flexibility and reducing blood viscosity, it helps in improving oxygen delivery to various tissues, alleviating symptoms like intermittent claudication and painful cramps caused by poor circulation.

Key Ingredients

The primary ingredient in OXIFYLINE PR 400 is Pentoxifylline (400mg), a methylxanthine derivative that works by inhibiting phosphodiesterase, leading to an increase in cyclic adenosine monophosphate (cAMP) levels, which in turn enhances vascular flow.

Key Benefits

1. Improves Blood Flow

Pentoxifylline (400mg) works by reducing blood viscosity and increasing the deformability of red blood cells, allowing them to pass through narrow blood vessels more easily. This helps in conditions such as intermittent claudication where blood supply to the limbs is reduced.

2. Reduces Pain and Cramps

By improving oxygenation of tissues, OXIFYLINE PR 400 alleviates pain, numbness, and cramps associated with peripheral arterial disease (PAD).

3. Beneficial for Cerebrovascular Disorders

It helps in managing conditions such as stroke, vascular dementia, and ischemic brain disorders by improving blood circulation in the brain.

4. Aids in Diabetic Neuropathy

Pentoxifylline (400mg) has shown benefits in patients suffering from diabetic neuropathy, where improved microcirculation can help reduce symptoms.

5. Anti-inflammatory Properties

This drug exhibits anti-inflammatory effects, which may be useful in conditions such as chronic venous insufficiency and Raynaud's phenomenon.

6. Prevents Blood Clots

By preventing platelet aggregation, it reduces the risk of blood clot formation, which is a key factor in deep vein thrombosis (DVT) and pulmonary embolism.

How Does It Work?

Pentoxifylline (400mg) works through multiple mechanisms:

• Improves Red Blood Cell Flexibility: Enhances erythrocyte deformability, allowing them to travel through narrow capillaries.

• Reduces Blood Viscosity: Decreases blood thickness, ensuring better circulation.

• Inhibits Platelet Aggregation: Prevents clots that may block blood flow.

• Increases Oxygen Delivery: Enhances oxygen supply to ischemic tissues, thereby reducing symptoms of pain and cramping.

• Modulates Inflammatory Response: Lowers levels of inflammatory cytokines, which may contribute to vascular diseases.

Directions for Use

• Dosage: The standard recommended dose of OXIFYLINE PR 400 is one tablet three times daily or as prescribed by a healthcare professional.

• Method of Administration: The tablet should be swallowed whole with water, preferably after meals to reduce gastric discomfort.

• Duration of Treatment: It is crucial to take the medication for the prescribed duration, even if symptoms improve.

• Avoid Crushing or Chewing: As it is a prolonged-release tablet, it should not be chewed or broken.

Side Effects

While OXIFYLINE PR 400 is generally well-tolerated, some patients may experience side effects, including:

Common Side Effects:

• Dizziness

• Nausea

• Headache

• Gastrointestinal discomfort

• Flushing

• Diarrhea

Rare but Serious Side Effects:

• Hypotension (Low Blood Pressure)

• Bleeding Disorders

• Allergic Reactions (rash, itching, swelling)

• Arrhythmias (Irregular Heartbeat)

• Liver Dysfunction

Precautions and Warnings

1. Pregnancy and Breastfeeding

• Should be used with caution during pregnancy and breastfeeding. Consult a doctor before use.

2. Liver and Kidney Disorders

• Patients with hepatic or renal impairment should take adjusted doses to avoid adverse effects.

3. Bleeding Disorders

• Since Pentoxifylline (400mg) affects platelet function, it should be used cautiously in individuals with bleeding tendencies or those on anticoagulant therapy.

4. Low Blood Pressure

• It can cause a drop in blood pressure, so individuals prone to hypotension should take it under medical supervision.

5. Interactions with Other Medications

• Anticoagulants (Warfarin, Heparin): May increase the risk of bleeding.

• Antihypertensive Drugs: Can enhance the effect of low blood pressure.

• Caffeine: As both are xanthine derivatives, excessive caffeine intake may lead to side effects.

Price and Availability in India

The approximate price of OXIFYLINE PR 400 varies between ₹150 - ₹300 for a strip of 10 tablets, depending on the brand and pharmacy location.

Conclusion

OXIFYLINE PR 400, containing Pentoxifylline (400mg), is a highly effective medication for improving blood circulation, particularly in patients suffering from peripheral vascular diseases, stroke-related complications, and diabetic neuropathy. With its ability to reduce blood viscosity, enhance oxygenation, and prevent blood clots, it plays a crucial role in vascular health. However, it should be taken under medical supervision to avoid potential side effects and drug interactions. Always follow the prescribed dosage and consult a healthcare provider for personalized advice on its use.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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