PANTOSTRUM LS 

Pantoprazole (40mg), Levosulpiride (75mg SR)

PANTOSTRUM LS combines two potent medications, Pantoprazole (40mg) and Levosulpiride (75mg SR), providing an effective solution for various gastrointestinal disorders. This guide covers the uses, dosage, side effects, interactions, and more to help you understand the benefits and precautions associated with PANTOSTRUM LS.

What is PANTOSTRUM LS?

PANTOSTRUM LS is a combination medication that includes Pantoprazole (40 mg), a proton pump inhibitor, and Levosulpiride (75 mg), a selective dopamine D2 receptor antagonist with prokinetic and antiemetic properties. This blend addresses issues like gastroesophageal reflux disease (GERD), functional dyspepsia, and other conditions requiring both acid suppression and enhanced gastrointestinal motility.

Uses of PANTOSTRUM LS

1. Gastroesophageal Reflux Disease (GERD): PANTOSTRUM LS is highly effective in treating GERD by reducing stomach acid production and enhancing gastric motility, alleviating symptoms like heartburn and acid regurgitation.
2. Functional Dyspepsia: The combination helps in managing functional dyspepsia by improving gastric emptying and reducing discomfort caused by delayed stomach emptying.
3. Peptic Ulcers: By decreasing gastric acid secretion, Pantoprazole aids in the healing of peptic ulcers, while Levosulpiride enhances gastric motility, promoting faster recovery.
4. Irritable Bowel Syndrome (IBS): Levosulpiride’s prokinetic action can be beneficial in managing IBS symptoms, providing relief from bloating, abdominal pain, and irregular bowel movements.

Mechanism of Action

1. Pantoprazole (40mg): Pantoprazole works by inhibiting the H+/K+ ATPase enzyme in the stomach lining, reducing the production of gastric acid. This helps in healing ulcers and preventing acid reflux.
2. Levosulpiride (75mg SR): Levosulpiride enhances gastrointestinal motility by blocking dopamine D2 receptors, promoting the release of acetylcholine, which stimulates smooth muscle contractions in the gut. Its antiemetic properties also help in reducing nausea and vomiting.

Dosage and Administration

• Dosage: The typical dosage of PANTOSTRUM LS is one tablet daily, preferably before a meal. The sustained release (SR) formulation of Levosulpiride ensures prolonged action, making it convenient with once-daily dosing.
• Administration: Swallow the tablet whole with water. Do not crush, chew, or split the tablet as it may affect the sustained release mechanism.

Side Effects

While PANTOSTRUM LS is generally well-tolerated, some patients may experience side effects, including:

1. Common Side Effects:

   • Headache
   • Dizziness
   • Diarrhea or constipation
   • Abdominal pain
   • Nausea

2. Serious Side Effects:

   • Severe allergic reactions (rash, itching, swelling)
   • Severe diarrhea (indicative of Clostridium difficile infection)
   • Abnormal heart rhythms (related to electrolyte imbalances)
   • Neurological symptoms (extrapyramidal symptoms like tremors, rigidity)

Precautions and Warnings

1. Allergies: Inform your healthcare provider if you have a history of allergies to Pantoprazole, Levosulpiride, or similar medications.
2. Medical Conditions: Discuss any existing medical conditions, particularly liver disease, kidney disease, electrolyte imbalances, and neurological disorders.
3. Pregnancy and Breastfeeding: The safety of PANTOSTRUM LS during pregnancy and breastfeeding is not well-established. Consult your doctor before use if you are pregnant or nursing.
4. Interactions: PANTOSTRUM LS can interact with various medications, including anticoagulants, antiplatelet drugs, certain antibiotics, and antiretrovirals. Provide a complete list of your current medications to your healthcare provider.

Drug Interactions

1. Anticoagulants and Antiplatelets: Pantoprazole may enhance the effect of these medications, increasing the risk of bleeding.
2. Methotrexate: Pantoprazole can increase methotrexate levels, potentially leading to toxicity.
3. Antiretrovirals: Some antiretrovirals may have reduced efficacy when taken with Pantoprazole.
4. CNS Depressants: Levosulpiride may enhance the sedative effects of CNS depressants, requiring dosage adjustments.

Lifestyle and Dietary Recommendations

1. Diet: Follow a balanced diet that avoids spicy, acidic, and fatty foods which can aggravate GERD symptoms.
2. Meal Timing: Avoid lying down immediately after meals to prevent acid reflux.
3. Exercise: Regular physical activity can improve gastrointestinal motility and overall well-being.

Storage and Handling

• Storage: Store PANTOSTRUM LS at room temperature, away from direct sunlight and moisture.
• Handling: Keep out of reach of children. Do not use the medication beyond its expiration date.

Conclusion

PANTOSTRUM LS, a combination of Pantoprazole (40mg) and Levosulpiride (75mg SR), offers a comprehensive treatment approach for various gastrointestinal disorders. By effectively reducing stomach acid production and enhancing gastric motility, it provides relief from conditions like GERD, functional dyspepsia, and peptic ulcers. Always follow your healthcare provider’s instructions regarding dosage and administration, and be aware of potential side effects and drug interactions. With proper use, PANTOSTRUM LS can significantly improve your gastrointestinal health and overall quality of life. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology.

For further information 

Email: info@sterispharma.com /  contact@sterispharma.com

Call/WhatsApp:  7877551268, 7849827488 

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