Piosteris M 500, a powerful combination medication, contains Pioglitazone and Metformin Sustained Release Tablets. It is a trusted therapeutic option for managing Type 2 Diabetes Mellitus, helping patients achieve better blood sugar control. By targeting insulin resistance and enhancing glucose metabolism, Piosteris M 500 is a comprehensive solution for maintaining long-term glycemic balance.

This article delves into the formulation, uses, benefits, side effects, and more about Piosteris M 500, offering detailed insights into its role in diabetes management.

Introduction

Type 2 Diabetes Mellitus, a chronic metabolic disorder, is characterized by elevated blood glucose levels due to insulin resistance or inadequate insulin secretion. Managing diabetes often requires a combination of medications to target different aspects of the disease.

Piosteris M 500, containing Pioglitazone and Metformin Sustained Release, provides a dual-action mechanism:

• Pioglitazone improves insulin sensitivity.
• Metformin Sustained Release (SR) reduces hepatic glucose production and enhances peripheral glucose uptake.

This synergistic approach ensures effective blood sugar control, reducing the risk of diabetes-related complications.

Key Ingredients

1. Pioglitazone

   • Category: Thiazolidinedione (TZD) class of antidiabetic agents.
   • Function: Reduces insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ), enhancing glucose utilization in peripheral tissues.
   • Benefits: Improves glycemic control without increasing insulin secretion.

2. Metformin Sustained Release (SR)

   • Category: Biguanide antidiabetic agent.
   • Function: Decreases hepatic glucose production, enhances peripheral glucose uptake, and improves insulin sensitivity.
   • Benefits: Offers a steady release for prolonged efficacy, minimizing gastrointestinal side effects.

Mechanism of Action

The Pioglitazone and Metformin Sustained Release Tablet work synergistically:

1. Pioglitazone:

   • Improves insulin sensitivity in muscles, adipose tissues, and the liver.
   • Reduces fasting plasma glucose (FPG) and HbA1c levels.
   • Enhances lipid profile by lowering triglycerides and increasing HDL cholesterol.

2. Metformin SR:

   • Inhibits gluconeogenesis in the liver.
   • Improves insulin sensitivity in peripheral tissues.
   • Reduces intestinal absorption of glucose.

Together, they provide sustained glucose control with reduced risk of hypoglycemia.

Key Benefits of Piosteris M 500

1. Effective Glycemic Control

   • Targets fasting and postprandial blood sugar levels.
   • Improves HbA1c levels, ensuring long-term diabetes management.

2. Dual-Action Formula

   • Combines the benefits of Pioglitazone and Metformin SR for enhanced efficacy.

3. Improved Insulin Sensitivity

   • Helps the body utilize insulin more effectively, reducing insulin resistance.

4. Cardiometabolic Benefits

   • Improves lipid profile by reducing triglycerides and increasing good cholesterol (HDL).
   • Lowers the risk of cardiovascular complications.

5. Weight Neutrality

   • Pioglitazone offers a mild weight gain benefit, especially for patients prone to significant weight fluctuations.

6. Reduced Risk of Hypoglycemia

   • Both ingredients work without overstimulating insulin secretion, minimizing hypoglycemia risk.

Uses of Piosteris M 500

Piosteris M 500 is primarily indicated for:

• Type 2 Diabetes Mellitus
  • For patients who do not achieve glycemic control with monotherapy.
  • As an adjunct to diet and exercise to enhance glucose metabolism.
• Insulin Resistance Management
  • Improves insulin sensitivity in patients with metabolic syndrome.

Dosage and Administration

1. Dosage:

   • The typical dosage of Piosteris M 500 is one tablet daily, administered with or after meals.
   • Dosage may vary depending on individual requirements and physician recommendations.

2. Administration Guidelines:

   • Swallow the tablet whole with water; do not crush or chew.
   • Maintain consistency in timing for optimal results.
   • Ensure adherence to dietary and exercise recommendations.

3. Missed Dose:

   • Take the missed dose as soon as you remember.
   • If it’s close to the next scheduled dose, skip the missed one.

4. Overdose:

   • Overdose symptoms may include severe hypoglycemia or lactic acidosis. Seek immediate medical attention if an overdose occurs.

Side Effects of Piosteris M 500

While Piosteris M 500 is generally well-tolerated, some patients may experience side effects:

1. Common Side Effects:

   • Nausea or vomiting.
   • Flatulence or abdominal discomfort.
   • Mild swelling due to Pioglitazone.
   • Fatigue or dizziness.

2. Rare Side Effects:

   • Lactic acidosis (associated with Metformin, though rare).
   • Edema or weight gain.
   • Low bone mineral density with prolonged Pioglitazone use.

3. Precautions to Avoid Side Effects:

   • Avoid alcohol consumption to minimize the risk of lactic acidosis.
   • Regularly monitor liver and kidney functions.
   • Stay hydrated and maintain an active lifestyle.

Precautions and Warnings

1. Contraindications:

   • Do not use in patients with severe renal or hepatic impairment.
   • Not suitable for Type 1 Diabetes or diabetic ketoacidosis.

2. Pregnancy and Lactation:

   • Should be avoided during pregnancy unless deemed necessary by a healthcare provider.
   • Not recommended during breastfeeding due to insufficient safety data.

3. Drug Interactions:

   • Avoid combining with alcohol, corticosteroids, or diuretics.
   • May interact with antihypertensives, anticoagulants, and certain antibiotics.

4. Lifestyle Adjustments:

   • Maintain a balanced diet with controlled carbohydrate intake.
   • Incorporate regular exercise to enhance insulin sensitivity.

Who Can Benefit from Piosteris M 500?

Piosteris M 500 is ideal for:

• Adults with Type 2 Diabetes Mellitus.
• Patients requiring a combination therapy for better glycemic control.
• Individuals with insulin resistance or prediabetic conditions.

Storage Instructions

• Store at a temperature below 30°C, away from direct sunlight and moisture.
• Keep out of reach of children.
• Check the expiry date before use.

Comparative Advantages of Piosteris M 500

1. Over Monotherapy:

   • Combines two antidiabetic agents for superior efficacy.
   • Addresses both insulin resistance and glucose production.

2. Over Alternative Combinations:

   • Offers a sustained release formulation for steady blood sugar control.
   • Minimizes gastrointestinal side effects common with immediate-release Metformin.

3. Cost-Effectiveness:

   • Provides dual-action benefits in a single tablet, reducing the need for multiple medications.

Lifestyle and Dietary Tips

1. Follow a Low-Glycemic Index Diet:

   • Include whole grains, legumes, vegetables, and lean proteins.

2. Avoid Sugary Foods:

   • Minimize consumption of processed sugars and high-carbohydrate snacks.

3. Stay Physically Active:

   • Engage in moderate-intensity exercises like walking, cycling, or swimming.

4. Regular Monitoring:

   • Check blood glucose levels regularly to track progress.

Frequently Asked Questions (FAQs)

1. Can I use Piosteris M 500 if I have kidney issues?

   • Patients with severe renal impairment should avoid this medication. Consult a healthcare provider for alternatives.

2. Does Piosteris M 500 cause weight gain?

   • Pioglitazone may cause mild weight gain in some patients, but this can be managed with a proper diet and exercise.

3. Is it safe to use alongside insulin?

   • Use with caution under the supervision of a healthcare provider to avoid hypoglycemia.

4. Can Piosteris M 500 replace insulin therapy?

   • No, it is not suitable for replacing insulin in patients with Type 1 Diabetes.

Conclusion

Piosteris M 500 offers an effective, dual-action approach to managing Type 2 Diabetes Mellitus. With the combined benefits of Pioglitazone and Metformin Sustained Release Tablets, it ensures improved insulin sensitivity, enhanced glycemic control, and reduced risk of complications.

This medication is a reliable choice for individuals struggling with uncontrolled blood sugar levels, helping them achieve a better quality of life. Always use Piosteris M 500 under the guidance of a healthcare provider and complement it with healthy lifestyle practices for optimal results.

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options. The company offers a wide range of healthcare products, catering to various medical needs, from rare disease treatments to essential healthcare products. Sterispharma's product range includes solutions for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. Medicines can be conveniently ordered via Our websites—Sterisonline, Sterisindia, and Sterispharma.

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