Introduction

PIRFENOID 400 is a medication containing Pirfenidone (400mg), which is widely used for the treatment of idiopathic pulmonary fibrosis (IPF). This chronic and progressive lung disease leads to scarring (fibrosis) of lung tissue, making it difficult for patients to breathe and decreasing oxygen supply to the body. Pirfenidone is an antifibrotic agent that helps slow down the progression of fibrosis and improves lung function.

Key Ingredients

The active ingredient in PIRFENOID 400 is Pirfenidone (400mg), which works by modulating the inflammatory and fibrotic pathways in the lungs. It has anti-inflammatory, antioxidant, and antifibrotic properties, helping in the management of idiopathic pulmonary fibrosis (IPF).

Key Benefits

• Slows Down Lung Fibrosis – Pirfenidone reduces lung scarring and slows disease progression in idiopathic pulmonary fibrosis.

• Improves Lung Function – Helps maintain better oxygen supply to the body by reducing fibrosis.

• Reduces Inflammation – Works by inhibiting pro-inflammatory mediators, thereby decreasing inflammation in the lungs.

• Enhances Quality of Life – Delays the need for oxygen therapy and helps patients maintain their normal activities for a longer time.

• Potential Use in Other Fibrotic Diseases – Researchers are studying Pirfenidone for its effectiveness in treating other fibrotic conditions.

How Does It Work?

Pirfenidone (400mg) in PIRFENOID 400 works by targeting key pathways involved in lung fibrosis:

1. Anti-Inflammatory Action – Suppresses the production of pro-inflammatory cytokines like TNF-alpha and interleukin-6, which contribute to lung damage.

2. Antifibrotic Mechanism – Inhibits TGF-beta, a key mediator of fibrosis, thereby reducing excessive tissue scarring.

3. Oxidative Stress Reduction – Lowers oxidative stress levels, preventing further lung damage.

By modulating these biological mechanisms, Pirfenidone significantly helps in delaying the progression of idiopathic pulmonary fibrosis.

Dosage and Administration

The recommended dosage of PIRFENOID 400 varies based on the patient’s condition and tolerance. A typical dosage schedule is:

• Initial Dose: 267 mg three times daily for the first week.

• Titration Phase: Gradually increased over two weeks.

• Maintenance Dose: Pirfenidone 400mg three times daily with food to minimize gastrointestinal side effects.

It is crucial to follow the doctor’s prescription and not to skip or overdose on the medication.

Side Effects

While PIRFENOID 400 is beneficial, some patients may experience side effects, including:

• Nausea and Vomiting – Taking the medication with food can help reduce nausea.

• Skin Reactions – Increased sensitivity to sunlight; using sunscreen and protective clothing is recommended.

• Fatigue and Dizziness – Some patients may feel tired or dizzy, so caution is advised when driving or operating heavy machinery.

• Loss of Appetite – A reduced desire to eat may be experienced.

• Liver Function Abnormalities – Regular liver function tests are necessary while on Pirfenidone.

Precautions and Warnings

• Avoid Alcohol Consumption – Alcohol can increase the risk of liver toxicity.

• Monitor Liver Enzymes – Regular tests should be done to check liver function.

• Use Sunscreen – Protection against sun exposure is necessary to avoid skin irritation.

• Caution in Kidney and Liver Disease – Patients with severe kidney or liver impairment should consult their doctor before taking Pirfenidone (400mg).

• Pregnancy and Breastfeeding – The safety of PIRFENOID 400 during pregnancy and breastfeeding is not well established; consult a healthcare provider before use.

Drug Interactions

PIRFENOID 400 may interact with other medications, including:

• CYP1A2 Inhibitors – Drugs like fluvoxamine and ciprofloxacin may increase Pirfenidone levels in the body.

• Smoking – Smoking can reduce the effectiveness of Pirfenidone, and it is advisable to quit smoking.

• Anticoagulants – Patients on blood thinners should monitor for increased bleeding risk.

• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) – May cause additional liver strain when used together with Pirfenidone.

Price and Availability in India

The price of PIRFENOID 400 varies based on the brand and pharmacy. In India, the approximate price range for a strip of 10 tablets is ₹600 – ₹1200, depending on the manufacturer and location.

Frequently Asked Questions (FAQs)

1. Can Pirfenidone (400mg) cure idiopathic pulmonary fibrosis (IPF)?

No, Pirfenidone does not cure IPF, but it helps in slowing the disease progression and improving lung function.

2. How long should I take PIRFENOID 400?

Pirfenidone is a long-term therapy and should be taken as prescribed by the doctor. Stopping it abruptly can worsen lung function.

3. What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it is close to the next dose, skip the missed dose and continue as scheduled.

4. Can I take Pirfenidone (400mg) with food?

Yes, taking PIRFENOID 400 with food reduces nausea and improves drug absorption.

5. Are there alternatives to Pirfenidone?

Yes, another antifibrotic drug used for IPF is Nintedanib, which also helps in reducing lung fibrosis.

Conclusion

PIRFENOID 400, containing Pirfenidone (400mg), is a crucial medication in managing idiopathic pulmonary fibrosis (IPF). It slows disease progression, reduces inflammation, and enhances the quality of life for patients. However, it should be taken with proper medical supervision, considering the potential side effects and precautions. Regular monitoring, lifestyle modifications, and adherence to the prescribed dosage can help optimize treatment outcomes.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

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