PIRFENOID 400 

Pirfenidone (400mg)

PIRFENOID 400, containing Pirfenidone (400mg), is a medication primarily used for the treatment of idiopathic pulmonary fibrosis (IPF).  Pirfenidone has been shown to slow the progression of this disease, improving patients' quality of life. This article will provide a comprehensive overview of PIRFENOID 400, including its uses, dosage, mechanism of action, side effects, precautions, and more.

Uses of PIRFENOID 400

Idiopathic Pulmonary Fibrosis (IPF)

PIRFENOID 400 is specifically indicated for the treatment of idiopathic pulmonary fibrosis. IPF causes the lung tissue to become thickened, stiff, and scarred over time, leading to severe breathing difficulties. Pirfenidone helps in managing this condition by slowing down the rate of fibrosis and reducing inflammation in the lungs.

Potential Benefits

• Improved Lung Function: PIRFENOID 400 can help maintain lung function by slowing the decline associated with IPF.
• Reduced Symptoms: Patients may experience a reduction in symptoms such as shortness of breath and chronic cough.
• Enhanced Quality of Life: By controlling the progression of IPF, Pirfenidone allows patients to maintain a better quality of life for a longer period.

Dosage and Administration

Standard Dosage

• Initiation: Treatment with PIRFENOID 400 typically starts with a lower dose that is gradually increased over two weeks to minimize side effects. The starting dose is 267mg taken three times daily.
• Maintenance: The maintenance dose is usually 800mg taken three times daily, which equals a total daily dose of 2400mg. PIRFENOID 400's 400mg tablets make it easier to achieve the desired dosage with fewer pills.

Administration Guidelines

• With Food: It is recommended to take PIRFENOID 400 with food to reduce gastrointestinal side effects.
• Consistent Schedule: Taking the medication at the same times each day helps maintain consistent levels of the drug in the bloodstream.

Mechanism of Action

• Antifibrotic Activity: It inhibits the production of fibrotic proteins such as collagen and fibronectin, which are involved in the scarring process.
• Anti-inflammatory Properties: Pirfenidone reduces the production of pro-inflammatory cytokines, thereby decreasing inflammation in the lungs.
• Antioxidant Effects: It has antioxidant properties that help protect lung cells from damage caused by oxidative stress.

Side Effects

Common Side Effects

• Skin Reactions: Rash and sensitivity to sunlight (photosensitivity) may occur.

Serious Side Effects

• Liver Dysfunction: Elevated liver enzymes can indicate liver damage, necessitating regular liver function tests.
• Photosensitivity Reactions: Severe skin reactions due to sun exposure require prompt medical attention.

Management of Side Effects

• Dose Adjustments: Reducing the dose or taking the medication with food can help manage gastrointestinal side effects.
• Sun Protection: Using sunscreen and wearing protective clothing can prevent photosensitivity reactions.

Precautions and Contraindications

Contraindications

• Severe Liver Disease: Patients with significant liver impairment should not take PIRFENOID 400.
• Allergy to Pirfenidone: Individuals with known hypersensitivity to Pirfenidone or any of its components should avoid this medication.

Precautions

• Liver Function Monitoring: Regular liver function tests are necessary to detect potential liver damage early.
• Kidney Function: Dose adjustments may be required for patients with renal impairment.
• Pregnancy and Breastfeeding: The safety of Pirfenidone during pregnancy and breastfeeding is not well established and should be used only if the potential benefits justify the risks.

Drug Interactions

Potential Interactions

• CYP1A2 Inhibitors: Medications such as fluvoxamine can increase the levels of Pirfenidone in the blood, leading to a higher risk of side effects.
• CYP1A2 Inducers: Smoking and certain medications can decrease the effectiveness of Pirfenidone by increasing its metabolism.

Recommendations

• Consult Healthcare Provider: Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
• Avoid Smoking: Smoking can reduce the effectiveness of PIRFENOID 400 and should be avoided.

Clinical Studies and Efficacy

Research Findings

• Clinical Trials: Multiple clinical trials have demonstrated the efficacy of Pirfenidone in slowing the progression of IPF.
• Patient Outcomes: Patients treated with PIRFENOID 400 have shown improved lung function, reduced disease progression, and better overall survival rates compared to those receiving a placebo.

Long-Term Benefits

• Sustained Efficacy: Long-term studies indicate that the benefits of PIRFENOID 400 in managing IPF persist over several years of treatment.
• Quality of Life: Consistent use of the medication can lead to sustained improvements in patients' quality of life by reducing symptoms and maintaining lung function.

Conclusion

PIRFENOID 400 (Pirfenidone 400mg) is a vital medication for managing idiopathic pulmonary fibrosis. Its antifibrotic, anti-inflammatory, and antioxidant properties make it effective in slowing disease progression and improving patient outcomes.  Patients taking PIRFENOID 400 should work closely with their healthcare providers to monitor their condition and optimize their treatment regimen. By adhering to the prescribed dosage and taking necessary precautions, patients with IPF can achieve better control over their condition and enhance their quality of life. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology

For further information

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