Introduction

PIRFENOID 400 is a pharmaceutical formulation containing Pirfenidone (400mg), a well-known antifibrotic medication primarily used to treat Idiopathic Pulmonary Fibrosis (IPF). This condition is characterized by progressive scarring of lung tissue, leading to difficulty in breathing. Pirfenidone helps slow down the disease's progression, improving lung function and enhancing the patient's quality of life. This article provides an in-depth understanding of PIRFENOID 400, covering its uses, dosage, side effects, mechanism of action, precautions, and pricing in India.

Key Ingredients

The active ingredient in PIRFENOID 400 is Pirfenidone (400mg), which exhibits antifibrotic, anti-inflammatory, and antioxidant properties. It works by inhibiting fibroblast proliferation and reducing the deposition of extracellular matrix proteins, thereby minimizing lung fibrosis.

Uses of PIRFENOID 400

1. Treatment of Idiopathic Pulmonary Fibrosis (IPF)

• Pirfenidone helps slow the decline of lung function in patients with IPF.

• It reduces lung scarring and helps improve oxygen exchange.

• Delays disease progression, helping patients maintain their physical activity levels.

2. Anti-Inflammatory Benefits

• Pirfenidone possesses anti-inflammatory properties, which help reduce lung inflammation and prevent excessive tissue damage.

3. Potential Role in Other Fibrotic Diseases

• Research suggests that Pirfenidone may also be beneficial in conditions like liver fibrosis, kidney fibrosis, and scleroderma-associated lung disease.

Dosage and Administration

Recommended Dosage

The standard dose of PIRFENOID 400 varies depending on the patient's tolerance and stage of the disease. A typical dosing regimen is as follows:

• Initial Dosage: 267 mg (one 267 mg tablet) three times daily for the first week.

• Gradual Increase: 534 mg (two 267 mg tablets or one 534 mg tablet) three times daily for the second week.

• Maintenance Dose: Pirfenidone (400mg) three times daily, gradually increasing to 600mg per dose as tolerated.

Administration Guidelines

• Take the tablet with food to minimize stomach discomfort.

• Swallow the tablet whole; do not crush or chew it.

• Do not miss doses, as this can impact the effectiveness of treatment.

• Avoid sudden discontinuation, as stopping abruptly may worsen the condition.

How Does PIRFENOID 400 Work?

Pirfenidone (400mg) exerts its effects through multiple mechanisms:

1. Antifibrotic Activity – Inhibits the proliferation of fibroblasts, which are responsible for scar tissue formation.

2. Anti-Inflammatory Effects – Reduces the release of pro-inflammatory cytokines like TNF-alpha, IL-1 beta, and TGF-beta, thereby decreasing lung inflammation.

3. Antioxidant Properties – Protects lung cells from oxidative stress and damage.

4. Reduces Collagen Synthesis – Helps prevent excessive collagen buildup, which contributes to lung fibrosis.

Side Effects of PIRFENOID 400

Like any medication, PIRFENOID 400 may cause some side effects. Common and severe side effects include:

Common Side Effects:

• Nausea and vomiting

• Loss of appetite

• Fatigue

• Dizziness

• Skin rash or itching

Serious Side Effects:

• Severe liver toxicity (elevated liver enzymes)

• Photosensitivity reactions (increased sensitivity to sunlight)

• Breathing difficulties or worsening lung symptoms

• Gastrointestinal issues like diarrhea or stomach pain

When to Seek Medical Attention?

• If you experience yellowing of the skin/eyes (jaundice), severe nausea, or unexplained weight loss, seek immediate medical care.

• If breathing worsens or severe dizziness occurs, discontinue Pirfenidone and consult a doctor immediately.

Precautions and Warnings

Who Should Avoid PIRFENOID 400?

• Patients with a history of severe liver or kidney disease.

• Those who have experienced severe allergic reactions to Pirfenidone.

• Pregnant or breastfeeding women, unless prescribed by a doctor.

Special Considerations

• Sun Protection: Due to photosensitivity, it is advised to use sunscreen and wear protective clothing when going outside.

• Alcohol Avoidance: Alcohol can increase liver toxicity when combined with Pirfenidone (400mg).

• Drug Interactions: Avoid taking with fluoroquinolones, strong CYP1A2 inhibitors, and certain antibiotics, as they may alter the drug’s effectiveness.

Price of PIRFENOID 400 in India

The price of PIRFENOID 400 varies depending on the brand and pharmacy. On average, a strip of 10 tablets costs between ₹800 – ₹1500. Prices may fluctuate based on location and manufacturer.

Conclusion

PIRFENOID 400 containing Pirfenidone (400mg) is an effective treatment for Idiopathic Pulmonary Fibrosis (IPF), helping slow disease progression and improve lung function. While the medication provides substantial benefits, it must be used cautiously due to potential side effects and drug interactions. Always consult a healthcare provider for the correct dosage and precautions before starting therapy.

By understanding the mechanism, uses, side effects, and pricing of PIRFENOID 400, patients can make informed decisions about their treatment and improve their respiratory health.

About The Author

STERIS HEALTHCARE PVT LTD

Steris Healthcare Pvt Ltd, known as Sterispharma, was founded in February 2018 by a team of experienced professionals in the pharmaceutical industry. Headquartered in Navi Mumbai, the company holds certifications from WHO, GMP, and ISO, reflecting its dedication to maintaining high standards of quality and safety. Sterispharma’s mission is to provide affordable, high-quality medications across India, strictly adhering to WHO guidelines. With the convenience of an online pharmacy, customers can easily order medicines with home delivery options.

For further information 

Email: info@sterispharma.com / contact@sterispharma.com

Call/WhatsApp: 8209542042 , 8824175417

BUY NOW