RABISTRUM DSR 40: A Comprehensive Guide to Rabeprazole and Domperidone

RABISTRUM DSR 40 is a combination medication that effectively treats various gastrointestinal disorders. It contains two active ingredients: Rabeprazole and Domperidone. This formulation is designed to alleviate symptoms associated with conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and functional dyspepsia. In this comprehensive guide, we will delve into the composition, mechanism of action, uses, dosage, side effects, price, and important safety information regarding RABISTRUM DSR 40.

Composition

RABISTRUM DSR 40 comprises:

• Rabeprazole Sodium - 40 mg
• Domperidone - 30 mg

Rabeprazole is a proton pump inhibitor (PPI) that works by reducing stomach acid production, while Domperidone is a prokinetic agent that enhances gastric motility and helps with the movement of food through the digestive tract.

Mechanism of Action

Rabeprazole

Rabeprazole inhibits the H+/K+ ATPase enzyme in the gastric parietal cells, which is responsible for the secretion of gastric acid. By blocking this enzyme, Rabeprazole effectively reduces the acidity in the stomach and duodenum, providing relief from acid-related disorders.

Domperidone

Domperidone works by blocking dopamine receptors in the gastrointestinal tract. This action promotes gastric emptying and prevents nausea and vomiting. By enhancing gastrointestinal motility, Domperidone helps to alleviate symptoms of nausea and bloating that may accompany acid-related conditions.

Uses of RABISTRUM DSR 40

RABISTRUM DSR 40 is primarily indicated for:

• Gastroesophageal Reflux Disease (GERD): RABISTRUM DSR 40 effectively manages GERD symptoms by reducing stomach acidity and improving gastric motility.

• Peptic Ulcers: This medication aids in the healing of peptic ulcers by decreasing gastric acid secretion and enhancing gastrointestinal motility.

• Functional Dyspepsia: RABISTRUM DSR 40 provides relief from symptoms such as bloating, nausea, and discomfort associated with functional dyspepsia.

• Nausea and Vomiting: The presence of Domperidone makes RABISTRUM DSR 40 effective in preventing nausea and vomiting, particularly in patients undergoing treatments that may induce these symptoms.

Dosage and Administration

Recommended Dosage

The typical dosage of RABISTRUM DSR 40 is:

• Adults: 1 tablet daily, taken before meals, preferably in the morning.

• Children: Dosage should be determined by a healthcare professional based on individual needs.

Administration Guidelines

• Swallow the tablet whole with water. Do not crush or chew the tablet.

• It is recommended to take the medication at least 30 minutes before a meal for optimal efficacy.

• Follow the prescribed dosage and duration as instructed by your healthcare provider.

Side Effects

While RABISTRUM DSR 40 is generally well-tolerated, some patients may experience side effects. Common side effects include:

• Headache: Some patients may experience headaches as a common side effect of Rabeprazole.

• Nausea: While Domperidone helps prevent nausea, some patients may still experience this side effect.

• Dizziness: Dizziness may occur, especially in patients who are sensitive to changes in blood pressure.

• Diarrhea or Constipation: Altered bowel habits may occur, though they are generally mild and self-limiting.

• Dry Mouth: Some patients may experience dryness in the mouth, which can be alleviated by staying hydrated.

Serious Side Effects

Though rare, some serious side effects may occur. Seek immediate medical attention if you experience:

• Severe Allergic Reactions: Signs include rash, itching, swelling, severe dizziness, or trouble breathing.

• Cardiac Arrhythmias: Domperidone can potentially affect heart rhythm; report any irregular heartbeats or palpitations to your doctor.

• Severe Gastrointestinal Issues: Symptoms like severe abdominal pain, persistent diarrhea, or blood in stools should be reported promptly.

Price

The price of RABISTRUM DSR 40 may vary based on location, pharmacy, and manufacturer. On average, the cost for a strip of 10 tablets ranges between ₹200 to ₹400 in India. It is advisable to check with local pharmacies for the most accurate pricing.

Safety Information and Precautions

Contraindications

RABISTRUM DSR 40 should not be used in the following conditions:

• Hypersensitivity: If you have a known allergy to Rabeprazole, Domperidone, or any other component of this medication.

• Severe Liver Disorders: Patients with severe liver impairment should avoid using this medication due to the risk of increased side effects.

• Prolactin-secreting Tumors: Domperidone is contraindicated in patients with prolactin-secreting tumors due to its effect on dopamine receptors.

Precautions

Before taking RABISTRUM DSR 40, inform your healthcare provider if you have:

• Kidney Problems: Patients with renal impairment should use this medication with caution.

• Cardiac Issues: Individuals with a history of heart disease or arrhythmias should be monitored closely while using Domperidone.

• Pregnancy and Lactation: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

Drug Interactions

RABISTRUM DSR 40 may interact with other medications. Inform your healthcare provider about all the medications you are currently taking, especially:

• Antibiotics: Certain antibiotics may interact with Rabeprazole.

• Antifungal Medications: Drugs like ketoconazole and itraconazole may have reduced absorption when used with Rabeprazole.

• Antidepressants: Some antidepressants can increase the risk of arrhythmias when taken with Domperidone.

Conclusion

RABISTRUM DSR 40 is a potent combination medication that effectively treats various gastrointestinal disorders, including GERD, peptic ulcers, and functional dyspepsia. Its dual action of reducing gastric acidity through Rabeprazole and enhancing gastric motility via Domperidone makes it a valuable option for patients seeking relief from uncomfortable digestive symptoms. As with any medication, it is crucial to follow the prescribed dosage and consult with a healthcare provider for personalized recommendations, especially if you have underlying health conditions or are taking other medications. By doing so, patients can maximize the benefits of RABISTRUM DSR 40 while minimizing potential risks.v Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, Sterisonline  ,  Sterisindia and Sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology. 

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