SAVELINER 400 

Sevelamer (400mg)

 SAVELINER 400 contains Sevelamer 400 mg a phosphate binder used primarily to manage hyperphosphatemia (elevated phosphate levels) in patients with chronic kidney disease (CKD) on dialysis. This medication plays a crucial role in maintaining proper phosphate balance, which is vital for bone health and preventing cardiovascular complications. This article delves into the uses, dosage, side effects, and other essential aspects of Sevelamer 400 mg.

Uses of SAVELINER 400

Hyperphosphatemia Management

Sevelamer 400 mg is used to control hyperphosphatemia in patients with chronic kidney disease (CKD) who are on dialysis. Hyperphosphatemia occurs when there is too much phosphate in the blood, which can lead to serious health problems, including bone and cardiovascular diseases. By binding phosphate in the digestive tract, Sevelamer prevents its absorption into the bloodstream, thereby reducing serum phosphate levels.

Cardiovascular Protection

Chronic kidney disease patients are at a higher risk of cardiovascular diseases due to elevated phosphate levels. Sevelamer helps mitigate this risk by reducing phosphate levels, which can help prevent vascular calcification and other cardiovascular complications.

Bone Health

High phosphate levels can lead to bone disorders, such as osteitis fibrosa and adynamic bone disease, in CKD patients. By controlling phosphate levels, Sevelamer supports better bone health and prevents these disorders.

Dosage and Administration

Initial Dosage

The initial dose of Sevelamer 400 mg for adults is typically one to two tablets three times daily with meals. The exact dosage depends on the patient's serum phosphate levels and the type of dialysis they are undergoing (hemodialysis or peritoneal dialysis).

Titration

The dose of Sevelamer should be adjusted based on the serum phosphate levels, aiming to maintain the levels within the target range of 3.5 to 5.5 mg/dL. Dosage adjustments are usually made every two to four weeks as needed.

Administration Tips

• With Meals: Sevelamer should be taken with meals to effectively bind dietary phosphate.
• Swallow Whole: Tablets should be swallowed whole and not crushed, chewed, or broken to ensure proper efficacy.
• Hydration: Patients should maintain adequate hydration to support kidney function and overall health.

Side Effects

Common Side Effects

• Gastrointestinal Issues: These symptoms are generally mild to moderate and often resolve with continued use or dose adjustment.
• Abdominal Pain: Some patients may experience abdominal pain or discomfort, which can be managed with appropriate dose modifications.

Serious Side Effects

• Bowel Obstruction: Although rare, there is a risk of bowel obstruction, particularly in patients with a history of gastrointestinal disorders. Symptoms include severe abdominal pain, bloating, and inability to pass stool or gas.
• Hypocalcemia: Low blood calcium levels can occur, necessitating monitoring and potential supplementation with calcium and vitamin D.

Allergic Reactions

While rare, allergic reactions to Sevelamer can occur. Symptoms may include rash, itching, swelling, severe dizziness, and difficulty breathing. Immediate medical attention is required if these symptoms arise.

Precautions and Contraindications

Medical History

Before starting Sevelamer, it is important to inform the healthcare provider of any medical history, especially:

• Gastrointestinal Disorders: Conditions like bowel obstruction, motility disorders, or severe constipation.
• Electrolyte Imbalance: Conditions such as hypocalcemia or hypercalcemia.
• Swallowing Difficulties: Difficulty swallowing tablets may require an alternative form of medication.

Drug Interactions

Sevelamer may interact with other medications, affecting their absorption and efficacy. It is essential to inform the healthcare provider of all medications being taken, including:

• Ciprofloxacin: Sevelamer can reduce the absorption of ciprofloxacin, an antibiotic.
• Thyroid Medications: Levothyroxine absorption may be reduced, necessitating monitoring of thyroid function.
• Anti-seizure Medications: Drugs like mycophenolate mofetil may have reduced absorption.

Pregnancy and Breastfeeding

There is limited data on the safety of Sevelamer during pregnancy and breastfeeding. It should be used during pregnancy only if clearly needed and prescribed by a healthcare provider.

Monitoring and Follow-up

Serum Phosphate Levels

Regular monitoring of serum phosphate levels is crucial to ensure the effectiveness of Sevelamer and to make necessary dose adjustments.

Calcium and Vitamin D

Monitoring calcium and vitamin D levels is important to prevent imbalances and manage bone health.

Gastrointestinal Health

Patients should report any persistent or severe gastrointestinal symptoms to their healthcare provider for appropriate management.

Conclusion

Sevelamer 400 mg (SAVELINER 400) is a valuable medication for managing hyperphosphatemia in chronic kidney disease patients on dialysis. By effectively reducing phosphate levels, it helps prevent serious complications related to bone and cardiovascular health. Proper administration, monitoring, and adherence to prescribed doses are essential for optimal outcomes. As with any medication, it is important to be aware of potential side effects and interactions, and to communicate openly with healthcare providers about any concerns or medical history. SAVELINER 400 continues to be a critical component in the management of chronic kidney disease, contributing to better quality of life and overall health for patients. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology.

For further information 

Email: info@sterispharma.com /  contact@sterispharma.com

Call/WhatsApp:  7877551268, 7849827488 

BUY NOW