TELMISTRUM TRIO 

Telmisartan (40mg), Cilnidipine (10mg), Chlorthalidone (12.5mg)

TELMISTRUM TRIO, which includes Telmisartan (40mg), Cilnidipine (10mg), and Chlorthalidone (12.5mg) in managing hypertension and related cardiovascular conditions, combination therapies are often preferred for their enhanced efficacy and comprehensive approach. This trio of medications works synergistically to control blood pressure, reduce cardiovascular risk, and improve overall patient outcomes.

Telmisartan (40mg)

Overview

 It works by preventing the action of angiotensin II, a hormone that causes blood vessels to constrict, thus helping to lower blood pressure and reduce strain on the heart.

Mechanism of Action

Telmisartan (40 mg) specifically inhibits the binding of angiotensin II to its receptor, which leads to vasodilation (relaxation of blood vessels) and reduced blood pressure. Additionally, Telmisartan helps to decrease the workload on the heart and has protective effects on the kidneys, particularly beneficial in diabetic patients.

Benefits and Uses

• Hypertension Management: Telmisartan effectively lowers blood pressure and helps prevent complications such as stroke, heart attack, and kidney damage.
• Cardiovascular Protection: It reduces the risk of cardiovascular events in patients with a high risk of heart disease.
• Diabetic Nephropathy: Provides renal protection in diabetic patients by reducing the progression of kidney damage.

Side Effects

Common side effects include dizziness, headache, and fatigue. Serious side effects are rare but may include kidney dysfunction and allergic reactions. Regular monitoring is advised to ensure safety and efficacy.

Cilnidipine (10mg)

Overview

Cilnidipine is a calcium channel blocker (CCB) used in the treatment of hypertension. It is a newer generation CCB that blocks calcium entry into the cells of blood vessels and the heart, leading to vasodilation and reduced blood pressure.

Mechanism of Action

Cilnidipine selectively inhibits L-type and N-type calcium channels, which helps in relaxing the blood vessels and reducing the heart's workload. This dual inhibition is unique and helps in controlling blood pressure more effectively compared to other CCBs.

Benefits and Uses

• Effective Blood Pressure Control: Cilnidipine is highly effective in managing hypertension, especially in patients who do not respond adequately to other antihypertensives.
• Reduced Risk of Peripheral Edema: Unlike some other CCBs, Cilnidipine has a lower risk of causing peripheral edema (swelling of the limbs).
• Improved Tolerability: Generally well-tolerated with fewer side effects compared to other calcium channel blockers.

Side Effects

Possible side effects include dizziness, flushing, and mild swelling of the ankles. Serious adverse effects are uncommon but can include heart palpitations or significant hypotension.

Chlorthalidone (12.5mg)

Overview

Chlorthalidone (12.5 mg) is a thiazide-like diuretic used for managing hypertension and edema (fluid retention). It works by promoting the excretion of sodium and water through the kidneys, which helps lower blood pressure and reduce fluid buildup in the body.

Mechanism of Action

Chlorthalidone acts on the distal convoluted tubule in the kidneys to increase the elimination of sodium and chloride. This leads to reduced fluid volume in the bloodstream, which helps in lowering blood pressure and alleviating symptoms of fluid retention.

Benefits and Uses

• Hypertension Management: Effective in reducing blood pressure and preventing related complications.
• Edema Control: Helps manage edema associated with conditions such as heart failure, renal impairment, and liver disease.
• Long-Lasting Effect: Offers a prolonged duration of action, which is beneficial for once-daily dosing.

Side Effects

Common side effects include increased urination, electrolyte imbalances, and dehydration. Rare but serious effects can include severe allergic reactions and significant drops in blood pressure. Regular monitoring of kidney function and electrolytes is recommended.

Synergistic Effect of TELMISTRUM TRIO

The combination of Telmisartan, Cilnidipine, and Chlorthalidone in TELMISTRUM TRIO offers a comprehensive approach to hypertension management:

• Enhanced Blood Pressure Control: Telmisartan and Cilnidipine work through different mechanisms to lower blood pressure, while Chlorthalidone adds an additional layer of efficacy by reducing fluid volume.
• Reduced Cardiovascular Risk: By combining these medications, the risk of cardiovascular events is minimized more effectively than with monotherapy.
• Improved Patient Outcomes: The combination therapy may improve adherence and outcomes, as the patient benefits from the combined effects of different drug classes.

Conclusion

TELMISTRUM TRIO, featuring Telmisartan (40mg), Cilnidipine (10mg), and Chlorthalidone (12.5mg), provides a powerful and multifaceted approach to managing hypertension. By leveraging the strengths of each medication, this combination therapy offers effective blood pressure control, reduces cardiovascular risk, and improves overall patient well-being. As with any medication regimen, it is important to use TELMISTRUM TRIO under the guidance of a healthcare professional to ensure safety and effectiveness. Steris Healthcare Pvt Ltd, operating as Sterispharma since its founding by expert professionals in the pharmaceutical industry in February 2018, is based in Navi Mumbai. The company is certified by WHO, GMP, and ISO, emphasizing its commitment to quality and safety. Sterispharma focuses on providing high-quality drugs at affordable prices throughout India, adhering strictly to WHO guidelines. Offering the convenience of an online pharmacy, customers can easily purchase medicines with home delivery options available. Sterispharma's mission is to supply a broad range of healthcare products to meet the diverse needs of the medical community. From advanced treatments and medications for rare conditions to essential health necessities, Sterispharma aims to serve the extensive demands of the healthcare industry. You can order medicines from Sterispharma through their websites, sterisonline and sterispharma. Their extensive product lineup includes treatments for Cardiology, Asthma, Respiratory Issues, Nasal Conditions, Diabetes, Endocrinology, Gastroenterology, Orthopedics, Anti-infectives/Antibiotics, General Medicine, Urology, Neurology, Nephrology, Oncology, Gynecology, Pediatrics, Dental Care, and Dermatology.

For further information 

Email: info@sterispharma.com /  contact@sterispharma.com

Call/WhatsApp:  7877551268, 7849827488 

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